I don't think there's necessarily any issue with Grienke, but in my opinion, might as well try to put him in the most comfortable situation possible, just to avoid any possibility, however remote, that he problems arise. I figure, assuming we end up with home field in the NLDS, an easy way to set the rotation would be Grienke and Yo at home in some order, Marcum and Wolf on the road, and then either Grienke or Yo for Game 5 at home. That way, Grienke gets to pitch at home, Yo gets to pitch at home (where I think he does better - I'm too lazy to check right now), Marcum and Wolf generally seem fine on the road, and then either the Game 2 pitcher can go on normal rest in Game 5, or the Game 1 pitcher can go on an extra day rest. Either way, your two best pitchers are available for that game.