It's tough, because of the contact even the most rested players can blow a knee out at any moment - i feel like in basketball the extra wear and tear and fatigue related to their insane travel schedule plays more of a role with preventable injuries. Plus next to nobody cares about the NBA regular season aside from Christmas day. With the NFL salary cap structure, it's really difficult to sit a star making 10-15% of your team payroll for a couple weeks in the middle of a season when each game honestly means so much for playoff positioning, and instead give all those snaps to a practice squad player barely holding onto a NFL roster spot. To me the closest thing some NFL teams do now is splitting carries between running backs and going with a heavy front 7 defensive rotation for snaps. With roster limitations, teams can't get too nuts with giving healthy starters games off with certain position groupings, too. Say you give a starting lineman a week off, then you get an in-game injury and poor performance by their backup and 3rd string lineman options, and you're stuck playing the rest of the game hoping your starting QB doesn't get killed with your best player at that position watching from the sideline in a sweatshirt. The other general load management improvement the NFL could do as a whole is add a 2nd bye week to the schedule.