Agree with Zurch. I'm not an engineer, but the job I've had the last 15 months consists of responsibilities and skills that I've done in bits and pieces throughout my career but never all at the same time and some of them I hadn't done in ten years. I took a shot at it because I thought the list of people who have market research, sales, CRM data/reports/dashboards, and people management experience is a short list to begin with, much less finding one who wants to live in a non-major-market. What I think put me over is that in a presentation they asked me to describe myself and what I would bring to the team and I showed an image of a Swiss Army Knife; I said that if you need the best Philips screwdriver that's not going to be me, but if you need a Philips screwdriver, flathead screwdriver, paring knife, bottle opener, and tweezers all in one person I'm it.
They offered me within 48 hours after the interview and more salary than what the recruiter told me they were looking to pay. Bill Belicheck supposedly says, "Don't tell me what a guy can't do - tell me what he can do." You may not be able to do everything in a job description, but focus on what you can do and show how you have learned new skills.