I'm probably one of only about 6 people in the world that is bothered by this but I can't stand when an ampersand is used when listing more than two things. For example, if I saw something that said, "Autograph signing today with Ryan Braun & Christian Yelich!" that wouldn't bother me. If it said, "Autograph signing today with Ryan Braun, Christian Yelich, and Lorenzo Cain!" that wouldn't bother me either. But if it said, "Autograph signing today with Ryan Braun, Christian Yelich & Lorenzo Cain!" that's like visual nails on a chalkboard to me. Even with an oxford comma after Yelich it still looks horrible. Drives me crazy. And don't even get me started if the sentence is broken into two lines and the ampersand starts the bottom line like, "Autograph signing today with Ryan Braun, Christian Yelich & Lorenzo Cain!"