The Simpsons has been faltering for some time now, but was incredible in its heyday. Family Guy, IMO, has similarly faltered, and had a shorter peak, which was also quite good. I'll judge these historically, with greater weight placed on the peak years. Peter Griffin vs Homer Simpson- Homer mops the floor with Peter. He set the mold for the modern-day animated drunken idiot dad. Lois Griffin vs Marge Simpson- close to a push for me, I'll go with a slight edge to Lois. Lisa Simpson vs Meg Griffin- I've never liked the Lisa character, or the Meg character for that matter, but they do add good things to the show by bringing an odd sense of balance. I go with Lisa by a nose. Bart Simpson vs Chris Griffin- Bart Dominates Stewie vs Maggie- Stewie is the best character on that show, by far and Maggie isn't much of a character, but an accessory. Brian vs Snowball/Santas little helper/Itchy and Scratchy- Brian's an actual character, the others are pets. Extended Family- (francis griffin/the pewterschmidts vs homer's dad/marge's sisters) - Marge's sisters and Abe Simpson are awesome. Other regular characters- (Swansons/Quagmire/Cleveland/Goldmans/Channel 5 news crew/Adam West vs Flanders/Burns/Smithers/Krusty/Barney/Moe/Nelson/Milhouse/Seymour/Wiggums - Simpsons other characters- Simpsons. So I go with the Simpsons pretty much winning everywhere there's a good comparison except a slight edge to Lois while Stewie and Brian are great characters with no real counterpart on the Simpsons. The secondary characters make the Simpsons great, and Homer is an icon. That's enough for me.