Don't stay in Wrigleyville unless you want to party like a 20 year old Iowa student with his parents credit card. As others have said, anywhere along the redline makes it easy to get to Wrigleyville. I would suggest the south loop. Its quiet on the weekend, has lots of good food and entertainment, and has reasonable prices on hotels. You would be looking at the Jackson or Harrison redline stops. My fiancé works at the Field Museum and puts people up in the Congress Hotel a lot. It's a little outdated, but has a great location and price. There are other options on trip advisor as well in the $150-175 range and I've never heard of a 2 night minimum. Barring that, around the Chicago stop or if you can spend a little more, the Grand stop. That's the touristy part just north of the loop with lots of bars and restaurants. Quartino's is a good, decent priced Italian place in that area if you are looking for suggestions. If you want to get off the Redline (I wouldn't blame you, its basically a toilet for bums and Cubs fans) you can use Uber. Just download the app and it makes getting around the city super easy. Otherwise, there are cabs everywhere but they are a bit more expensive. Hope that helps, let me know if you have other questions. I've lived here for about 10 years now from Evanston to the loop to Wicker Park and now the south side.